A joint International Meeting - The 5th International Sympisium Peptide Receptors & Kinin 2009

Final Scientific Program

Friday, June 26

15h00 – 18h00 Registration

19h00 Introductory Remarks
Rémi Quirion, McGill University, Canada
François Marceau, Laval University, Kinin 2009
Réjean Couture, President, Canadian Branch, INPS
Abba Kastin, President, INPS

Opening lectures
19h15 Jean-Pierre Changeux (Collège de France, Paris, France)
The nicotinic acetylcholine receptor: from molecular biology to consciousness

19h45 Gold Medal Recipient, Frey-Werle Foundation of the Henning L. Voigt Family
Oscar Carretero (Detroit, USA)
Ac-SDKP, a tetrapeptide: Role in target organ damage in hypertension and diabetes

20h15 Welcoming Reception and light Dinner

Saturday, June 27

Session I
From a peptide to a drug : Rational drug design
Chairs: Fernando Albericio & Alain Fournier

8h30 – 8h55 Alain Couvineau (Paris, France)
Structure-function relationship of the VPAC1 receptor: a prototypical of class B GPCR

8h55 – 9h20 Les Miranda (Thousand Oaks, CA, USA)
Conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

9h20 – 9h45 Catherine Llorens-Cortes (Paris, France)
Apelin receptors in body fluid homeostasis and cardiovascular functions

9h45 – 10h10 Ross Bathgate (Melbourne, Australia)
Relaxin family peptide receptors: Unusual G-protein coupled receptors and novel therapeutic targets

10h10 – 10h45 Break

10h45 – 11h10 Jocelyn Dupuis (Montréal, Canada)
Development of radiolabeled adrenomedullin analogs designed for molecular imaging of the pulmonary circulation

11h10 – 11h35 Fernando Albericio (Barcelona, Spain)
Kahalalide F: from the sea to clinical trials

11h35 – 12h00 Girolamo Calo (Ferrara, Italy)
Pharmacology and neurobiology of neuropeptide S

12h00 – 14h00 Complimentary Lunch

Session II
Peptide receptors: In vivo molecular pharmacology
Chairs: Emiliana Borrelli & Martin Beaulieu

14h00 – 14h25 Michael Bader (Berlin, Germany)
Kinin receptors as drug targets: Evidence from genetically altered animal models

14h25 – 14h50 Martin Beaulieu (Québec, Canada)
Arrestin mediatiated signaling in vivo: from behavior to protein complex

14h50 – 15h15 Laura Bohn (Columbus, OH, USA)
Functional selectivity of receptor signaling hinges on beta-arrestin₂

15h15 – 15h45 Emiliana Borrelli (Irvine, CA, USA)
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors

15h40 – 16h15 Break

16h15 – 16h40 Raul Gainetdinov (Genova, Italy)
Trace amine associated receptor 1 (TAAR1) as emerging therapeutic target

16h40 – 17h05 Alan Kopin (Boston, MA, USA)
Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function

17h05 – 17h30 Alexander Faussner (Munich, Germany)
Microenvironment of TYR7.53 in the NPxxY sequence of the human bradykinin B2 receptor controls and regulates interaction with receptor kinases and arrestins

Sunday, June 28

Session III
Hypertension, diabetes and obesity
Chairs: Jean-Pierre Girolami & Réjean Couture

8h30 – 8h55 Driss Rochdi (Montreal, Canada)
Water reabsorption disorders and the vasopressin system : one therapeutic target and several approaches

8h55 – 9h20 Madhu Anand-Srivastava (Montréal, Canada)
Natriuretic peptide receptor C and regulation of blood pressure: molecular mechanisms

9h20 – 9h45 Carsten Tschöpe (Berlin, Germany)
Kinin receptors and cardiac inflammation under diabetic conditions

9h45 – 10h10 Jean-Pierre Girolami (Toulouse, France)
Bradykinin B2 receptor and perspectives in renal protection against diabetic nephropathy

10h10 – 10h45 Break

10h45 – 11h10 Ronaldo C. Araújo (Sao Paulo, Brazil)
Obese mice deficient for kinin receptors exhibit hyperglycemia, insulin resistance and hepatic abnormalities

11h10 – 11h35 Edward P. Feener (Boston, MA, USA)
Kallikrein-kinin system in diabetic retinopathy

11h35 – 12h00 Didier Pruneau (Paris, France)
Kinin B1 receptor blockade: a promising treatment of diabetic retinopathy

12h00 – 14h00 Complimentary Lunch

Session IV
Poster Session I (odd numbers)
Chair: Pedro d’Orléans-Juste

14h00 – 16h00

16h15 – 17h00 Samuel Weiss (Calgary, Canada)
Plenary Lecture - NeuroStem cells: from discovery to clinical applications

17h00 Cocktail

Monday, June 29

Session V
Inflammation, immunology and blood chemistry
Chairs: Michael Bader & François Marceau

8h30 – 8h55 Keith R. McCrae (Cleveland, OH, USA)
Biology of the kininogen deficient mouse

8h55 – 9h20 Karim Maghni (Montréal, Canada)
A novel mechanism of regulation of FcεRI receptor function: the TAC1/TAC1R tachykinergic system

9h20 – 9h45 Joao Batista Calixto (Florianopolis, Brazil)
New advances about the role of B1 and B2 receptors for kinins in persistent pain and inflammatory processes

9h45 – 10h10 Amrita Ahluwalia (London, UK)
Endothelial Kinin B1 receptors and inflammatory cell recruitment

10h10 – 10h45 Break

10h45 – 11h10 Mami Noda (Fukuoka, Japan)
Bradykinin as an attractant of immune cells in the brain and its possible neuroprotective role

11h10 – 11h35 Jacques Hébert (Québec, Canada)
Bradykinin B2 antagonist icatibant is efficacious in treatment of subsequent hereditary angioedema attacks: results from open-label extension phase of two phase II trials

11h35 – 12h00 Nancy Brown (Nashville, TN, USA)
Bradykinin: The good, the bad, and the ugly

12h00 – 14h00 Complimentary Lunch

Session VI
Poster Session II (even numbers)
Chair: Pedro d’Orléans-Juste

14h00 – 16h00

19h00 Award Ceremony:
Prizes of the Frey-Werle Foundation of the Henning L. Voigt Family:
Allocution by Professor Hans Fritz, Governor of the Foundation.

Promotion Prize: Professor Nancy J. Brown, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee (presented by Prof. B. Schölkens).

Commemorative Medal: Professor Oscar A. Carretero, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan (presented by Prof. D. Regoli).

Poster Awards

20h30 Symposium Dinner, L’Astral

Tuesday, June 30

Session VII
Pain
Chairs: Philippe Walker & Yves De Koninck

8h30 – 9h00 Rohini Kuner (Heidelberg, Germany)
The role of Gq/G11-mediated GPCR signalling in acute and chronic pain: novel insights via conditional deletion approaches

9h00 – 9h30 Marc Landry (Bordeaux, France)
Neuropeptide modulation of synaptic transmission through Gal1/GAGAB receptor interaction

9h30 – 10h00 Philippe Saret (Sherbrooke, Canada)
Neurotensin receptors: new therapeutic targets for the treatment of chronic pain

10h00 – 10h30 Break

10h30 – 11h00 Ru-Rong Ji (Boston, MA, USA)
Chemokine regulation of synaptic plasticity and persistent pain via neural-glial interaction

11h00 – 11h30 Rémi Quirion (Montréal, Canada)
Possible roles of calcitonin gene-related peptide and adrenomedullin in nociception and the development of morphine tolerance

11h30 – 12h00 Yves De Koninck (Québec, Canada)
A novel approach to detect interactions in intact tissue; NK-1 receptor homo-oligomerization

12h00 – 14h00 Complimentary Lunch

Session VIII
Neuropeptides in CNS disorders: 1^st Meeting of the Canadian Branch of the International Neuropeptide Society
Chairs: Henri Doods & Rémi Quirion

14h00 – 14h25 Abba Kastin (Baton Rouge, LA, USA)
Neuropeptide concepts with emphasis on the leptin receptors

14h25 – 14h50 Fred Nyberg (Uppsala, Sweden)
New aspects for the substance P system being a target for treatment of chronic pain and addictive diseases

14h50 – 15h15 Henri Doods (Biberach, Germany)
CGRP antagonists for the treatment of migraine and pain

15h15 – 15h45 David Vaudry (Rouen, France)
Characterization of the neurotrophic effects of PACAP and development of new analogs for future therapeutic applications

15h40 – 16h15 Break

16h15 – 16h40 Seiji Shioda (Tokyo, Japan)
Feeding regulation in the brain – novel GPCR ligands

16h40 – 17h05 Ted George (Bethesda, MD, USA)
Neurokinin 1 receptor antagonism as a potential therapy for alcoholism

17h05 – 17h30 Illana Gozes (Tel Aviv, Israel)
The drug candidate davunetide modulates microtubule dynamics in cells

17h30 – 18h00 Concluding Remarks
Domenico Regoli (Ferrara, Italy)

Poster Session

Posters are on display in the Ballroom Foyer, from Saturday 7h30 to Tuesday 12h00

Authors are requested to be present during one of the two Poster Sessions: for odd numbers, Sunday June 28, 14:00-16:00; for even numbers, Monday June 29, 14:00-16:00.

P1 Calo', G., Rizzi, A., Salvadori, S., Regoli, D., Guerrini, R. UFP-112 a potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor.

P2 Bourgault, S., Vaudry, D., Couvineau, A., Laburthe, M., Vaudry, H., Fournier, A. Probing the active conformation of the neuropeptide PACAP.

P3 Létourneau, M., Bourgault, S., Langlois, C., St-Hilaire, V., Chatenet, D., Fournier, A. A new look at endothelin-1 pharmacological studies.

P4 Doan, N.D., Bourgault, S., Chatenet, D., Vaudry, D., Vaudry, H., Fournier, A. Structure-activity relationship studies of N-terminal domain of PACAP.

P5 Chatenet, D., Létourneau, M., Fournier, A. Iterative approach to the discovery of novel urotensin ll-related peptide analogs: substitutions at position 4.

P6 Leprince, J., Gutiérrez-Pascual, E., Martinez-Fuentes, A.J., Pinilla, L., Guilhaudis, L., Segalas-Milazzo, I., Tena-Sempere, M., Malagón, M.M., Castaño, J.P., Vaudry, H. Structure-activity relationship study of KiSS-10: identification of an antagonist of GPR54.

P7 Fortin, J.-P., Zhu, Y., Beinborn, M., Kopin, A.S. An alanine scan of membrane-thethered glucose-dependent insulinotropic polypeptide (GIP) highlights the functional role of the C-terminus.

P8 Xu, J., Carretero, O.A., Zhu, L., Rhaleb, N.-E., Shesely, E.G., Yang, X.P. Blockade of B1 kinin receptor exacerbates DOCA-salt-induced hypertension and cardiac hypertrophy in B2 knockout mice.

P9 De Brito Pereira, H., Talbot, S., Couture, R. The anti-hypertensive effect of kinin B1 receptor antagonists in two rat models of hypertension.

P10 El Andalousi, J., Anand-Srivastava, M. Implication of different components of cell cycle progression in the antiproliferative effect of NPR-C in VSMC.

P11 Paula, R.D., Todiras, M., Alenina, N., Bader, M., Santos, R.A.S. Mas-dependent and independent mechanisms of potentiation of bradykinin hypotensive effect by angiotensin-(1-7) in mice.

P12 Santos, E.L., de Picoli Souza, K., Silva, E.D., Batista, E.C., Martins, P.J.F., D’Almeidac, V., Pesquero, J.B. Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats.

P13 Souza, K.P., Santos, E.L., Batista, E.C., Silva E.D., Reis, F.C.G., Silva, S.M.A., Luz, J., Pesquero, J.B. Effect of kinin B2 receptor lack in postnatal myostatin gene expression and repercussion in adult life.

P14 Noronha, S.M.R., Corrêa, S.A.A., Poletti, E.F., Lopes,D.D., Sforça, M.L., Shimuta, S.I., Zanchin, N.I.T., Nakaie, C.R., Silva, I.D.C.G. Synthesis, purification and structural analysis of mutants peptides L262D259-272 and L265D259-272 of the AT1 receptor.

P15 Noronha, S.M.R., Corrêa, S.A.A., Geraldo, M.V., Nogueira-de-Souza, N.C., Carvalho, C.V., Costa, A.M.M., Linhares, J.J., Gomes, M.T.V., Silva, F.C., Cavalcante, J.B., Siufi-Neto, J., Marks, G., Siufi, A.A., Kimura, E.T., Silva, I.D.C.G. Angiotensin ll type 1 receptor (A168G and T825A) and angiotensin-converting enzyme (T5529C) polymorphisms and breast cancer among Brazilian women.

P16 Al-Khoury, J., Kamal, M., Issa, N., Choufani, F., El-Khoury, C., D’Orléans-Juste, P., Jacques, D., Bkaily, G. Angiotensin ll receptors AT1 but not AT2 undergo internalization and modulate cytosolic and nuclear calcium in human vascular endothelial cells.

P17 Provost, C., El-Helou, G., Hantouche, C., Perreault, C., Bkaily, G., Jacques, D. Angiotensin ll, a cardiac hypertrophic factor, also induces hypertrophy of human endocardial endothelial cells.

P18 El-Helou, G., Provost, C., Hantouche, C., Perreault, C., Bkaily, G.,Jacques, D. Angiotensin ll, a modulator of the survival of human endocardial endothelial cells.

P19 Cuerrier, C.M., Simard, É., Benoit, M., Guillemette, G., Gobeil Jr, F., Grandbois, M. Real-time monitoring of angiotensin ll-induced contractile response and cytoskeleton remodeling in individual cells by atomic force microscopy.

P20 Cuerrier, C.M., Simard, É., Gagner, A., Lebel, R., Gobeil Jr, F., Grandbois, M. Effect of thrombin and bradykinin on endothelial cell mechanical properties monitored through membrane deformation : an AFM study.

P21 Reis, R.I., Restini, C.B., Santos, E.L., Pecher, C., Schanstra, J.P., Bascands, J.-L., Casarini, D.E., Oliveira, E.B., Bendhack, L.M., Pesquero, J.B., Costa-Neto, C.M. Mutagenesis in angiotensin ll AT1 receptor reveals critical structural features for activation of different signaling pathways.

P22 Clément, M., Cabana, J., Leduc, R., Guillemette, G., Lavigne, P., Escher, E. Structural changes associated to receptor activation in the liganded angiotensin ll receptor AT1.

P23 Arsenault, J., Holleran, B.J., Proulx, C., Lavigne, P., Guillemette, G., Leduc, R., Escher, E. Incorporation of a non-canonical photolabelling residue into the angiotensin ll type 1 receptor for the identification of interacting partners.

P24 Dejda, A., Létourneau, M., Doan, N.D., Fournier, A. Photoaffinity labeling of the human PAC1 receptor.

P25 Catanzaro, O., Dziubecki, D., Obregon, P., Labal, E., Rodriguez, R.R. Antidiabetic efficacy of bradykinin antagonist R- 954 on glucose tolerance test in diabetic type 1 mice.

P26 Montpas, N., Leclair, P., Bachelard, H., Marceau, F., Adam, A. Altered cardiac bradykinin metabolism in experimental diabetes caused by variations of the activities of angiotensin converting enzyme and other peptidases.

P27 Tidjane, N., Talbot, S., Girolami, J.-P., Couture, R. Kinin B1 receptor as a therapeutic target in septic shock and diabetes.

P28 Pena Dias, J., Talbot, S., Pilon, M., Sénécal, J., de Champlain, J., Ferrari, B., Carayon, P., Couture, R. Kinin B1 receptor as a therapeutic target in the treatment of diabetes.

P29 Talbot, S., Chahmi, E., Pena Dias, J., Couture, R. Key role for spinal microglial kinin B1 receptor in diabetic pain neuropathy.

P30 Sinha, S., Clermont, A.C., Phipps, J.A., Chilcote, T.J., Feener, E.P. A novel plasma kallikrein inhibitor decreases retinal vascular permeability in animal models of diabetes and hypertension.

P31 Pouliot, M., Talbot, S., Vaucher, E., Pruneau, D., Couture, R. Topical admininstration of kinin B1 receptor antagonist FV-60135-02 inhibits retinal inflammation in streptozotocin-diabetic rats.

P32 Bhoola, K., Sia, Y., Shaw, O., Misso, N., Thompson, P. Expression and demethylation of kallikrein and kinin receptor genes in lung carcinoma cells.

P33 Bhoola, K., Wong, J., Ng, A., Shaw, O., Misso, N., Thompson, P. Expression and epigenetic regulation of kallikreins and kinin receptors in pleural mesothelioma cells.

P34 Corrêa, S.A.A., Noronha, S.M.R., Figueira, R.C.S., Geraldo, M.V., Silva, F.C., Cavalcante, J.B., Siufi-Neto, J., Marks, G., Siufi, A.A., Sogayar, M.C., Gebrim, L.H., Silva, I.D.C.G. Decreased expression of angiotensin-converting enzyme 1 and angiotensin ll type 1 receptor in breast cancer tissue specimens.

P35 Corrêa, S.A.A., Noronha, S.M.R., Alecrim, C., Shimuta, S.I., Nakaie, C.R., Gebrim, L.H., Silva, I.D.C.G. Peptides angiotensin-(1-7) and angiotensin ll in T47D breast cancer cells produce cAMP and proliferation opposing responses.

P36 Silva Jr, J.A., da Silva, M.P., Silva, M.P., Jasiulionis, M.G., Pesquero, J.B., Costa, M.S. Modulation of BCL-2 and BAX expression in kinin B1 receptor deficient mice with experimental melanoma after photodynamic therapy.

P37 Ehrenfeld, P., Conejeros, I., Toledo, C., Pavicic, M.F., Matus, C.E., Molina, L., Figueroa, C.D., Hidalgo, M.A., Burgos, R.A. Kinin B1 receptor regulates the release of metalloprotease-2 in breast cancer cells.

P38 Jegham, H., Roy, J., Maltais, R., Poirier, D. A novel aminosteroid induces cell cycle arrest and apoptosis of HL-60 cells.

P39 Morand-Contant, M., Anand-Srivastava, M., Couture, R. Synergistic interaction between angiotensin ll and endothelin-1 in the up-regulation of kinin B1 receptor expression in vascular smooth muscle cells.

P40 Bawolak, M.-T., Fortin, S., Bouthillier, J., Adam, A., Gera, L., C.-Gaudreault, R., Marceau, F. Signaling, desensitization and downregulation of bradykinin B2 receptors: emerging properties of inactivation-resistant stimulants.

P41 Buleon, M., Allard, J., Pecher, C., Praddaude , F., Blaes, N., Tack, I., Girolami J.P. Chronic ACE inhibition delays glomerular aging in nod mice and prevents age-related changes in expression and signaling of TGFß receptor II via B2 kinin receptor.

P42 Bourdet, B., Pecher, C., Minville, V., Jaafar, A., Blaes, N., Girolami, J.P., Tack, I. Distribution and expression of B2-kinin receptor on human leukocyte subsets in young adults and eldery: a new methodology using flow cytometry.

P43 Pecher, C., Couture, R., Tack, I., Girolami, J.P. Signalling effects of a kinin B2 receptor agonist on MAP kinase and IRS-1 activation induced by insulin in mesangial cell (MC).

P44 Mehrenberger, M., Pecher, C., Tack, I., Girolami, J.P. Effect of bradykinin on ICAM-1 synthesis by cultured mesangial cells and subsequent effect on monocyte adhesion.

P45 Dornelles, F.N., Santos, D.S., Van Dyke, T.E., Batista E.L. Jr., Calixto, J.B., Campos, M.M. Resolvin E1 downregulates the effects of P. gingivalis LPS on the expression of kinin B1 receptors.

P46 Kuhr, F., Zhang, Y., Brovkovych, V., Tan, F., Skidgel, R.A. The role of β-arrestin in B1 receptor-dependent activation of iNOS.

P47 Koumbadinga, G.A., Montpas, N., Adam, A., Marceau, F. Regulation of bradykinin receptor expression in human umbilical vein endothelial cells (HUVECs).

P48 Figueroa, C.D., Barría, M., Pavicic, M.F., Matus, C.E., Aguilar, M., Ehrenfeld, P. Stimulation of the kinin B1 receptor in human endothelial cells induces the expression of the intercellular adhesion molecule ICAM-1.

P49 Parreiras-e-Silva, L.T., Lira, E.C., Kettelhut, I.C., Navegantes, L.C.C., Costa-Neto, C.M. Modulation of kallikrein-kinin and renin-angiotensin systems components in skeletal muscle of septic rats.

P50 deBlois, D., Duguay, D., Kieu, A.-M., Wagner, F., Lahjouji, K., Moreau, M.-E., Newman, N., Fernandes, J.-C., Benderdour, M., Adam, A., Couture, R., Moldovan, F. Enhanced macrophage expression of kinin B1 receptor in human arthritic synovium.

P51 Rydlewski, M., Cruz-Silva, I., Praxedes-Garcia, P., Gozzo, A.J., Simões, M.J., Viel, T.A., Buck, H.S., Araújo, M.S. Possible involvement of kallikrein 7 in a psoriasis model.

P52 Cruz-Silva, I., Gozzo, A.J., Praxedes-Garcia, P., Carmona, A.K., Viel, T.A., Nunes, V.A., Buck, H.S.,Tanaka, A.S., Araújo, M.S. Effect of a kallikrein inhibitor in an in vivo lung edema model.

P53 Almeida, S.S., Crozariol, D.G., Haro, A.S., Barros, C.C., Rosa, T.S., Moraes, M.R., Alves, M.F., Carmona, A.K., Bacurau, R.F.P., Araújo, R.C. Plasma angiotensin l-converting enzyme activities from N- and C-domains are modulated by insertion/deletion polymorphism.

P54 Batista, E.C., Batista, E.C., Reis, F.C., Souza, K.P., Haro, A.S., Crozariol, D.G., Wasinski, F., Moraes, M.R., Barros, C.C., Bacurau, R.F., Araújo, R.C. Kinin B2 receptor deficiency promotes gastrocnemius muscle hypertrophy and impair swimming training responses.

P55 Welman, M., Castellanos, L., Maghni, K. SYK kinase plays a central role in the crosstalk between the FcεRI receptor and the tachykinergic-1 system.

P56 Vasquez-Pinto, L.M.C., Nantel, F., Jancar, S., Sirois, P. Bradykinin antagonists modulate eosinophil activation and VEGF and TGF-β levels in asthma.

P57 Rowan, M.P., Berg, K.A., Roberts, J.L., Hargreaves, K.M., Clarke, W.P. Rapid modulatory effects of bradykinin on nociception: a key component in an intricate signaling network.

P58 Guethe, L.M., Pelegrini-da-Silva, A., Rosa, E., Juliano, M.A., Prado, W.A., Martins, A.R. Endogenous angiotensin lll can modulate the nociceptive control mediated by the periaqueductal gray matter.

P59 Ma, W., Dumont, Y., Inoue, W., Luheshi, G., Quirion, R. Chronic PGE2 treatment is able to increase the synthesis of the pain-related peptides substance P and calcitonin gene-related peptide in cultured sensory ganglion explants.

P60 Wang, Z., Ma, W., Chabot, J.G., Quirion, R. Activation of neuron-localized CaM kinase-CREB signalling mediates CGRP involvement in the development of tolerance to morphine-induced analgesia.

P61 Hong, Y., Chabot, J.-G., Quirion, R. Co-localization of adrenomedullin with its receptor components, CLR and RAMPs in rat dorsal root ganglia.

P62 Rae, G.A., Schroeder, S.D., Chichorro, J.G., Calixto, J.B., Luiz, A.P. Role of kinin B1 and B2 receptor mechanisms in nociception in a mouse model of orofacial neuropathy.

P63 Takenoya, F., Kageyana, H., Date, Y., Nakazato, M., Shioda, S. Neuronal interaction between neuropeptide W (NPW) and other feeding regulatory peptides in rat brain.

P64 Dumont, Y., Mahaut, S., Moyse, E., Fournier, A., Quirion, R. Alterations of neuropeptide Y receptor subtypes in the dorsal vagal complex under acute feeding adaptations in the adult rat.

P65 Kageyama, H., Niijima, A., Takenoya, F., Shioda, S. Effects of galanin-like peptide (GALP) on the autonomic nervous system in the rat.

P66 Côté, J., Lepage, M., Fortin, D., Gobeil Jr, F. Selective tumour blood brain barrier opening with the kinin B2 receptor agonist [Phe8ψ(CH2NH)Arg9]-BK in a F98 glioma rat model: a MRI study.

P67 Bovenzi, V., Savard, M., Gobeil Jr, F. Protective effects of bradykinin against brain microvascular endothelial cell death induced by apoptotic stimuli.

P68 Maciel, I.S., Vianna, A.F., Dornelles, F.N., Campos, M.M., Calixto, J.B. Relevance of kinin B1 receptors for depressive behavior induced by E. coli LPS in mice.

P69 Lemos, M.T.R., Amaral, F.A., Bittencourt, M.F.Q.P., Caetano, A.L., Dong, K.E., Pesquero, J.B., Viel, T.A., Buck, H.S. Role of kinin B1 and B2 receptors on memory consolidation during aging process of mice.

P70 Caetano, A.L., Viel, T.A., Bittencourt, M.F.Q.P., Araujo, M.S., De Angelis, K., Buck, H.S. Changes of central kinin B2 receptor binding sites after exercise training in rats.

P71 Viel, T.A., Amaral, F.A., Dong, K.E., Bittencourt, M.F.Q.P., Caetano, A.L., Pesquero, J.B., Buck, H.S. Participation of kinin receptors on memory impairment after chronic infusion of human amyloid 1-40 (AB) peptide in mice.

P72 Viel, T.A., Dong, K.E., Amaral, F.A., Lemos, M.T.R., Bittencourt, M.F.Q.P., Caetano, A.L., Buck, H.S. Evaluation of bradykinin (BK) involvement on learning and short term memory of rats.

P73 Pereira, M.G., Becari, C., Souza, L.L., Oliveira, J.A., Salgado, M.C.O., Garcia-Cairasco, N., Costa-Neto, C.M. The angiotensin(1-7) Mas receptor is upregulated in a rat model of temporal lobe epilepsy.

P74 Pereira, M.G., Becari, C., Oliveira, J.A., Salgado, M.C.O.,Garcia-Cairasco, N., Costa-Neto, C.M. Modulation and functional participation of the renin-angiotensin system in a rat model of epilepsy.

P75 Rodi, D., Buzzi, A., Zucchini, S., Binaschi, A., Ongali, B., Mazzuferi, M., Boschi, A., Pasquali, M., Couture, R., Simonato, M. Involvement of the bradykinin system in epilepsy: a new hypothesis.

P76 Qadri, F., Schadcok, W., Haeuser, W., Heidbreder, M., Depping, R., Mueller, D.N., Bader, M., Dominiak, P. Acute HPA-axis response to a single LPS administration: involvement of kinin receptors and nitric oxide synthase.

P77 Silva Jr, J.A., Gouveia, T.L.F., Scorza, F.A., da Silva, M.P., Araújo, T.R., Cavalheiro. E.A., Naffah-Mazzacoratti, M.G. Rats in status epilepticus, treated with lovastatin, show downregulation of kinin B1 receptor in the hippocampus.

P78 Silva Jr, J.A., Goto, E.M., Silva, M.P., Perosa, S.R., Argañaraz, G.A., Pesquero, J.B., Teixeira, V.P.C., Naffah-Mazzacoratti, M.G. Expression of hippocampal neuropeptides and AKT pathway activation in the pilocarpine model of epilepsy in rats.

P79 Lacoste, B., Riad, M., Ratté, M.-O., Boye, S.M., Lévesque, D., Descarries, L. Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus.

P80 Culman, J., Tauer, U., Hunt, S.P., Zhao, Y. Central effects of neurokinin A require an interaction between the NK-1 and NK-2 receptors.

P81 Cameron, D.B., Galas, L., Raoult, E., Jiang, Y., Vaudry, H., Vaudry, D., Komuro, H. Involvement of PACAP in the control of cerebellar granule cell migration.

P82 Morales-Medina, J.C., Dumont, Y., Benoit, C.E., Quirion, R. Neuropeptide Y Y1 and Y2 receptors reverse behavioural despairs by increasing neurogenesis.

P83 Cloutier, F., Lauschke, J., Waite, P.M.E., Carrive, P. Compensatory mechanisms to maintain blood pressure in paraplegic rat: implication of central tachykinin NK-3 receptors?

P84 Salesse, C., Topolnik, L. VIP-induced long-term synaptic plasticity in hippocampal inhibitory interneurons.

P85 Bawolak, M.-T., Gera, L., Morissette, G., Marceau, F. Endocytosis of large cargoes mediated by the agonist-stimulated bradykinin B2 receptors.

P86 Houde, M., Carrier, E., D’Orléans-Juste, P. Alterations in platelet reactivity in the apolipoprotein E knock out mouse.

P87 Godin, A.G., Costantino, S., Lorenzo, L.-E., Swift, J.L., Sergeev, M., Ribeiro-da-Silva, A., De Koninck, Y., Wiseman, P.M. Spatial intensity distribution analysis (SPIDA), measuring protein densities and oligomerization states across cellular compartments.

P88 Swift, J.L., Godin, A.G., Sergeev, M., Wiseman, P.W.. Beaulieu, J.M. Quantitative characterizaiton of EGFR-GPCR transactivation using spatial intensity distribution analysis (SpIDA).